General and Reproduction Toxicology

Intox is as an experienced GLP complaint preclinical testing partner with over 25 years of experience in conducting safety assessment studies. From designing a complete study program to running every single test, Intox can address all your requirements. Safety Assessment studies are performed in compliance with global regulatory guidelines such as ICH, FDA, EMA, EU, OECD, OPPTS, JMAFF, CIB. We work in a collaborative manner, using our expertise to accomplish the safety assessment of your product. Toxicology testing defines the hazards from product exposure and plays a critical role in ensuring the safety of humans, animals and environment.

Rely on our toxicology testing capabilities when it comes to acute/single dose and repeat dose study designs (subacute/chronic). Our expert team enables the shortest turnaround time for study completion to expedite regulatory submissions. They can implement all dose routes including dietary, oral gavage, dermal, inhalation and parenteral in all laboratory animals viz., rats, mice, rabbits, Guinea pig, hamster, dog and NHP. All animal experiments are reviewed and approved by the Institutional Animal Ethics Committee (IAEC). Our 50-room animal facility is approved by the CPCSEA, Government of India, and meets global standards of maintenance and operation as prescribed by CPCSEA. Historical data accumulated over the years is available on in-life parameters, clinical and anatomic pathology, genetic toxicology and DART studies.

Acute Six pack / Single Dose toxicity

  • Acute oral toxicity in rat/mice
  • Acute dermal toxicity in rat
  • Acute inhalation toxicity in rat
  • Eye irritation test in rabbit
  • Skin irritation test in rabbit
  • Skin sensitization test in guinea pig
  • LLNA skin sensitization in mice

Repeat Dose Studies in rodents and non-rodents

  • Sub-acute toxicity 7/10/14 days
  • Sub-acute toxicity 28 days in rats/mice/rabbits (OECD 407)
  • Sub-chronic toxicity 90 days in rats/mice (OECD 408)
  • Subacute inhalation in rats (OECD-412)
  • Chronic toxicity (180 and 360 days) in rats/mice
  • Carcinogenicity and combined Carci (OECD 451, 452 and 453)
  • Subacute dog (OECD 409)

Developmental and Reproductive Toxicology

  • Reproduction/developmental toxicity screening test (OECD 421)
  • Combined repeated dose toxicity study with reproduction / developmental toxicity screening (OECD 422)
  • Extended one generation- EOGRTS (OECD 443)
  • Developmental neurotox (OECD 426)
  • Prenatal developmental toxicity / embryo-fetal developmental study (Segment II, ICH S5(R3), OECD 414; rats and rabbits)
  • Fertility and embryonic development study (Segment I, ICH S5(R3))
  • Pre-and postnatal study (Segment III, ICH S5(R3))
  • Juvenile toxicity study

Special Toxicology (single/repeat dose)

  • Immunotoxicology
  • Neurotoxicology
  • Ocular toxicology
  • Ototoxicity testing
  • Phototoxicology