IND-Enabling Toxicology Solutions

From your first toxicology study to IND data submission in just 9 months.

At INTOX, we deliver comprehensive IND-enabling toxicology solutions designed to accelerate your path to first-in-human clinical trials. Our integrated preclinical engine brings together toxicology, ADME, pharmacology, bioanalysis, and quality assurance in one seamless flow-reducing development time without compromising scientific quality or regulatory confidence.

Why Our Approach Works

Rapid IND Readiness

Rapid IND Readiness

From first toxicology study to IND submission in as little as 9 months - driven by optimized timelines, parallelized workflows, and proactive risk management.

Modality-Specific Expertise

Modality-Specific Expertise

Subject matter experts tailor study designs to your asset type - whether small molecules, biologics, or emerging modalities - ensuring fit-for-purpose strategies from the outset.

Leadership with Regulatory Insight

Leadership with Regulatory Insight

Your program is led by DABT-certified toxicologists and histopathology experts, providing deep mechanistic insight and regulatory foresight.

Integrated Teams Across Continents

Integrated Teams Across Continents

An aligned toxicology, ADME, pharmacology, and independent QAU team operating across India and the USA troubleshoots issues rapidly and strengthens your IND package in real time.

Advanced Bioanalytical Precision

Advanced Bioanalytical Precision

Our LC-MS/MS and broad bioanalytical platform delivers reliable quantification in complex matrices, evaluating exposure and toxicokinetic data for regulators.

Global Large-Animal Capabilities

Global Large-Animal Capabilities

Benefit from centrally managed large animal programs with access to premier facilities in the US, Europe, and Asia, all coordinated through a single accountable partner.

Hands-On Scientific Leadership

Hands-On Scientific Leadership

A dedicated Chief Scientific Officer, experienced program leaders, and proactive project managers guide your asset seamlessly from discovery through IND and beyond.

Robust Global Logistics

Robust Global Logistics

Our global supply chain and logistics management keep your studies on schedule with seamless movement of test articles and samples across regions for US and EU submissions.

End-to-End IND-Enabling Support

We help biotech and pharmaceutical developers generate regulatory-aligned nonclinical safety data that supports high-impact IND submissions. Our services span exploratory studies, full nonclinical safety assessment programs, and dossier support - ensuring alignment with global regulatory expectations, including US FDA, EMA, and other international agencies.

Our IND-Enabling Services

Exploratory & Lead-Selection Studies

  • PK/In-vitro ADME profiling
  • mini-hERG liability screening
  • Rodent MTD / tolerability assessments
  • Early decision-enabling PK and safety insights

Nonclinical Safety Assessments

Test Species

  • Rodents: Rats, mice
  • Non-rodents: Dogs, minipigs, NHPs (through partner facilities)

Routes of Exposure

  • Oral (gavage, dietary)
  • Parenteral (IV, SC, IM, ID)
  • Dermal, inhalation
  • Others: Intranasal, ocular, intra-vitreal, otic, intra-articular

Study Types Offered

  • Acute, subacute, subchronic, and chronic toxicity
  • 7-day (DRF), 14-day, 28-day, 90-day, 180-day, and 12-month repeat-dose studies
  • Long-term carcinogenicity (18–24 months)
  • Tg.rasH2 6-month carcinogenicity

Safety Pharmacology

  • CNS: Modified Irwin test
  • Cardiovascular: Dog telemetry studies
  • Respiratory: Whole-body plethysmography
  • In vitro hERG assay
  • ICH-aligned core battery evaluations

Genetic Toxicology

  • In vitro and in vivo genotoxicity evaluations
  • AMES bacterial reverse mutation test
  • Mammalian cell gene mutation tests
  • Chromosomal aberration and micronucleus assays

Bioanalytical & Dose Formulation Support

Capabilities

  • Method development, qualification & validation (LC-MS/MS)
  • TK/PK sample analysis and exposure profiling
  • Dose formulation analysis for nonclinical studies

Assay Platforms

  • TK/PK for small and large molecules
  • Matrices: Blood, plasma, serum, urine, tissue

Advanced Analytics

  • TK/PK modeling using WinNonlin®
  • Immunogenicity (ADA)
  • Immunotoxicology
  • Biomarker analysis
  • Acute-phase proteins
  • Biodistribution and persistence studies

Modalities

  • Novel biologics
  • Vaccines
  • Biosimilars
  • Novel small molecules

Regulatory Dossier Support

  • Authoring of IND Module 2 (summaries) & Module 4 (nonclinical reports)
  • Data integration and gap assessment
  • Support for IND strategy and submission planning

IND in 9 Months

Nonclinical Safety Assessment of NCE - IND in 9 Months

Studies/Weeks 1-4 5-8 9-12 13-16 17-20 21-24 25-28 29-32 33-36
Analytics  
DF-method development & validation 4  
BA method development & validation - Rat 5  
BA method development & validation-Non-rodent   5  
General Tox  
MTD & 7-10 days repeat dose DRF with TK in Rat   5  
MTD & 7-10 days repeat dose DRF with TK in Non-rodent   8  
4 Week in Rat with 2 or 4 Week recovery - Rat   18  
4 Week in Non-rodent with 2 or 4 Week recovery Non-rodent   20  
Safety Pharmacology  
CNS in Rat   6  
RESP in Rat   6  
HERG-patch clamp.   4  
CVS - Dog telemetry   10  
Mutagenicity  
AMES test   4  
In vitro CA or MNT   8  
This timeline represents a comprehensive integrated approach covering analytical method development, repeat-dose toxicology with toxicokinetics, safety pharmacology, and genetic toxicology - all optimized for a 9-month IND-enabling submission.

Nonclinical Safety Assessment of NBE – IND in 9 Months

Studies/Weeks 1-4 5-8 9-12 13-16 17-20 21-24 25-28 29-32 33-36
BA method development-Rat 4  
BA method validation - Rat   6  
BA partial method validation - NHP   8  
DF method development 2  
DF method validation   3  
Immunogenicity: method development in Rat 8  
Immunogenicity: method validation in Rat   8  
Immunogenicity: method development in NHP 8  
Immunogenicity: method validation in NHP   8  
   
Single dose & DRF in Rat*   8  
Single dose & DRF in NHP*   12  
   
4 Week in Rat with 2 or 4 Week recovery - Rat   18  
4 Week in NHP with 2 or 4 Week recovery - NHP   20  
This timeline reflects pivotal studies customized for biologic entities, including immunogenicity method development, single-dose and DRF studies across relevant species, and regulatory-aligned pivotal toxicology.

Why Global Innovators Trust Us

  • 30 years of safety assessment expertise, delivering regulatory confidence across global development programs.
  • 20,000+ GLP studies completed, demonstrating scale and consistency in toxicology research.
  • OECD GLP-compliant and AAALAC-accredited facilities producing data accepted by major regulators, including the US FDA and EMA.
  • Experience supporting submissions to international agencies such as EMA, ECHA, EFSA, EPA, and others - reducing regulatory surprises and smoothing review paths.

High-quality data generation supports compliance with global registration requirements and enables effective internal decision-making throughout molecule development.

Accelerate with Confidence

At INTOX, we don’t just conduct studies-we engineer IND-enabling pathways that are scientifically rigorous, regulator-ready, and execution-driven. Whether you’re advancing a new chemical entity or a novel biologic, our full spectrum of toxicology capabilities ensures you progress toward the clinic with certainty and speed.

Connect with our experts to begin your IND journey.


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